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In the tibial nerve crush model, nicotine treatment significantly suppressed GAP43 expression and functional reinnervation as measured by myelinated action potential and electromyography of gastrocnemius

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however, this became non-significant (RR = 1.04, 95% CI = 0.801.35) once additionally adjusted for alcohol consumption [53]

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E-Cigarette Flavors and Type of Device While they examined any potential confounding effects of e-cigarette flavoring on respiratory symptoms, the studys authors did not find a significantly higher incidence of any respiratory symptoms with flavors other than tobacco compared to never users