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[31] Fusing the binding portion of TNF receptor proteins to the heavy chain of an immunoglobulin molecule to force receptor dimerization, [31] they produced chimeric reagents with surprisingly high affinity and specificity for both TNF and a closely related cytokine called lymphotoxin, low antigenicity, and excellent stability in vivo

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An alternative easy method for antibody purification and analysis of proteinprotein interaction using GST fusion proteins immobilized onto glutathioneagarose