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Grapp M, Just IA, Linnankivi T, Wolf P, Lucke T, Hausler M et al

[21] 6-Phosphoglucono--lactone + H 2 O 6-Phosphogluconate Oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate In the final step of the oxidative phase, 6-phosphogluconate undergoes an oxidative decarboxylation , producing: ribulose 5-phosphate, a keto-pentose

Patients who report a severe delayed immune-mediated reaction (eg, drug reaction with eosinophilia and systemic symptoms, Stevens-Johnson syndrome or toxic epidermal necrolysis, acute generalized exanthematous pustulosis, drug-induced nephritis or hepatitis) should subsequently avoid the culprit drug, as this can be regarded as a contraindication to future use