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Most cases of nicotine poisoning are described following ingestion of nicotine-containing products

Researchers at Johns Hopkins University, who looked at the smoking habits of more than 300,000 adults for almost 20 years, found that men and women who smoked as few as two cigarettes daily had a 60% increased risk of death from any cause compared to those who never smoked

10.1016/j.taap.2019.02.006 91

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Additionally, individuals who used e-cigarettes for longer than three years not only exhibit reduced microvascular function but also diminished macrovascular dysfunction, implying that those who use the product for a longer time are at risk of systemic vascular effects [128]