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Cigarette smoke was also shown to induce up-regulation of MHC class II, CD86 (B7-2), PDL2 and down-regulation of Inducible T-Cell Costimulator Ligand (ICOSL) on airway DCs

400% TAX ON TOBACCO The Indian government has implemented significant tax hikes on tobacco products, with cigarettes seeing a 400% increase in excise duty

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(Spence said hes spending $400 more per acre on pesticides.) Black shank, a problematic fungus in southern tobacco states, is a particular concern