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Due to the lack of unpaired electrons, H 2 O 2 is not a free radical but a potent oxidant that can oxidize mitochondrial components (proteins, lipids, DNA)

b , Relative cell number of indicated SLC25A39 knockout Jurkat cells transduced with indicated sgRNAs

For instance, a minimum intracellular selenium status (in terms of the concentration of hydrogen selenide) is required for the translation of all seleno-GPxs

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Oxidation of DNA and RNA results in the modified nucleotides 8-hydroxy-deoxyguanosine (8OHdG) and 8-hydroxy-guanosine (8OHG) respectively