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An estimated 500 people died through causes directly attributable to smoking in Malta between 1999 and 2013

Marijuana users, on average, smoke only two to three times a month, so the typical exposure to marijuana is much lower than for tobacco. And marijuana is one where a lot of people dabble with it in their late teens and 20s, and some people continue with relatively low levels for a long period of time, Kertesz added

One study found that smoking reduced the number of motile sperm, which are essential for fertilization

The Associated Press reported April 2 that a study of lung-cancer patients found that nicotine appears to protect cancer cells from chemotherapy drugs like gemcitabine, cisplatin, and taxol

Bupropion (Zyban) : Originally developed as an antidepressant, bupropion reduces withdrawal symptoms and craving through effects on dopamine and norepinephrine systems