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This concept has notably been tested in conjunction with chimeric antigen receptor (CAR) T cell therapy (198, 212, 213)

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Edwards KD, Fernandez-Pozo N, Drake-Stowe K, Humphry M, Evans AD, Bombarely A, Mueller L (2017) A reference genome for Nicotiana tabacum enables map-based cloning of homeologous loci implicated in nitrogen utilization efficiency