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One randomized study that tested the effects of cold gloves and boots in 135 patients receiving carboplatin, docetaxel, or paclitaxel for breast cancer reported significantly less cold sensitivity, hand and foot numbness, and hand tingling in the cryotherapy group compared with the control group (Xu 2023)

There is a striking and concerning lack of human evidence

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(2018) Quantitative MRI in early intervertebral disc degeneration: T1rho correlates better than T2 and ADC with biomechanics, histology and matrix content

Increased lipid peroxidation in sera of ALS patients: a potential biomarker of disease burden