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It exists naturally in human plasma, saliva, and urine with plasma concentrations averaging ~200 ng/mL at age 20 but declining to ~80 ng/mL by age 60

In this review we briefly summarize the mechanisms of GSH synthesis and homeostasis, while we will focus on the strict connection between GSH levels and oxidative/nitrosative stress and on the downstream redox changes that modulate signaling pathways involved in viral infection and autophagy (ATG)

These important interactions are beyond the scope of this initial investigation, but will be incorporated in future studies

Med 10.1056/NEJMoa2306434 (2023)

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