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Increased NNMT activity has been observed in several metabolic research models and is associated with altered energy expenditure and disrupted NAD+ recycling

doi: 10.2174/1381612043452875 158 JeanninPDelnesteYLecoanet-HenchozSGauchatJFLifePHolmesDet al

Mitten, P

PD-L1 regulates tumor proliferation and T-cell function in NF2-associated meningiomas

Figure 3 shows no significant alteration in the docked compounds conformation after 100 ns MD simulation in reference to initial poses, suggesting that docked ligands maintained the strong interactions with essential residues in the catalytic pocket during MD simulation interval and established the formation of stable complexes