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Importantly, this implies that FSP1 may be essential not only in cancer resistance to ferroptosis but also in physiological contexts such as adipose tissue metabolism, where regulation of neutral lipid oxidation is critical for maintaining tissue homeostasis

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Most of the intracellular iron is used by macrophages for its incorporation into iron-binding proteins, contributing to diverse effector functions such as mitochondrial respiration, DNA repair, or immune responses defense against pathogens (including the abovementioned Nox2 and iNOS, for example) (8486)

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