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There are a small number of people who are allergic to PG, and more who have what is known as a PG sensitivity, making it uncomfortable for them to vape or inhale vapour containing PG, but this is relatively rare, and those with a sensitivity who want to continue to vape can use majority or 100% VG e-liquids

The FDA determined that "due to substantially lower amounts of harmful constituents than cigarettes and most smokeless tobacco products, such as moist snuff and snus, the authorized products pose lower risk of cancer and other serious health conditions than such products." Meghan Morean, a research scientist at the Yale School of Medicine, said, "It's good that we're moving towards a harm reduction approach

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Vape flavors have been the subject of similar debatesblamed for enticing youth, although they have key importance for many adults seeking to quit smoking