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Exclusive smokeless tobacco users maintained a similar adjusted odds ratio of 2.04 (95% CI: 1.113.74, p=0.022), and poly-tobacco users continued to display a markedly elevated risk, with an adjusted odds ratio of 5.54 (95% CI: 1.0230.06, p=0.047)

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"it has been linked to a reduction in the thickness of layers in the brain, and to brain lesions, involving areas such as the frontal lobe, which plays a role in voluntary movement and control of thinking, and a decrease in activity in the area of the brain that processes vision," said Silverstein