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282 When UA levels are elevated, RAGE signaling is stimulated, leading to the activation of nuclear factor-kappa B (NF-B)

This duration of safety monitoring provides meaningful reassurance about sustained exposure effects that would not be apparent in brief trials

The % of cytotoxicity was measured using the following formula: Click-iT plus TUNEL assay To perform TUNEL Alexa Fluor Staining, the commercial Click-iT TUNEL Alexa Fluor Imaging Assay (C10247, Invitrogen , Warsaw, Poland) was used in accordance with the instructions provided by the manufacturer

Cadmium induces multi-organ toxicity, primarily targeting the liver by disrupting hepatocyte function and activating cell death pathways

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