Mitochondrial dysfunction, oxidative stress, inflammation, and impaired ATP production occur in a feedforward cycle, serving as both consequences and causes of the marked reduction in glucose metabolism in the brain across the spectrum of ADRD development (Wang et al., 2017)
This effect may be attributed to its targeting of ADAM17, which facilitates the IL-23/IL-23R/Th17 cell axis [50], or its repression of Ets1 expression [51]
The plasmids and strains constructed in the present study are listed in Table 2
Harker LA, Ross R, Slichter SJ, and Scott CR (1976)
The Role of Antioxidants in Supporting Detoxification Processes Antioxidants can help support the body's detoxification processes by neutralizing free radicals and reducing oxidative stress, which can damage cells and impair detoxification mechanisms