nitrosamines in tobacco The Effect of Smoke N-Nitrosamines, NNK and NDEA, and Nicotine, on DNA Mismatch Repair Mechanism and miRNA Markers, Hypopharyngeal Squamous Cell Carcinoma: An In Vivo Model and Clinical Evidence IARC Publications Website - Smokeless

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In this experiment, the phosphorylation levels of AMPK-ACC proteins in the CSC exposure group were significantly increased, while the expression levels of Hmgcr and CYP7A1 protein were significantly decreased, which suggested that CSC exposure was able to affect glucose and lipid metabolism by AMPK-ACC and CYP7A1 gene expression or phosphorylation

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