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IL-1 has been found to be capable of promoting tumor cells to metastasize, by activating the cancer-related inflammation cascade (102,103)

During terminal differentiation of keratinocytes, skin barrier proteins such as filaggrin, loricrin and involucrin are concentrated into the cornified envelope, a layer gradually replacing the cytoplasmic membrane of keratinocytes and forming a template for the arrangement of the extracellular lipids 11

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