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Physiological Roles of ROS During spermatogenesis and epididymal transit, appropriate amounts of ROS are required for the oxidation of cystein-thiol groups essential for chromatin compaction and stabilization in spermatozoa (Figure 1A, ROS are furthermore implicated in the production of the mitochondrial capsule through the oxidation of protein thiols catalyzed by phospholipid hydroperoxide glutathione peroxidise

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Clarifying the specific role of ferroptosis in the onset of atherosclerosis, as well as its role in other organ lesions, still requires attention and participation of more researchers