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Magnesium has been reported to be essential to the functions of the enzyme gamma glutamyl transpeptidase (GGT), an enzyme that plays an important role in the biosynthesis of glutathione by breaking down circulating extracellular glutathione thus releasing cysteine for intracellular re-assembly of glutathione [10]

Therefore, STAT3 inhibitors (e.g., isoproterenol, thiostreptozotocin, etc.) can be used to induce ferroptosis

Four UGT families have been identified in humans: UGT1, UGT2 involving UGT2A and UGT2B subfamily, UGT3 and UGT8

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Former FDA official Dr