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Efficacy Data: Response rate: 54% (dextromethorphan-bupropion) vs 34% (placebo) at 6 weeks Remission rate: 39.5% (dextromethorphan-bupropion) vs 17.3% (placebo) at 6 weeks MADRS change: -14.9 (dextromethorphan-bupropion) vs -12.1 (placebo) at 6 weeks (GEMINI trial) Time to response: 1 week (significant improvement seen at week 1) Source Why it might interest you: Very rapid onset (within 1 week), novel mechanism (NMDA antagonism), and lower rates of sexual dysfunction and weight gain than standard antidepressants

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