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Although further research is warranted to elucidate the underlying mechanisms and confirm these findings, our study serves as a valuable resource for policymakers seeking to improve public health in rural and peri-urban regions of developing nations

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In this case, the data show that these nicotine pouch products meet that bar by benefiting adults who use cigarettes and/or smokeless tobacco products and completely switch to these products. Additionally, the FDA found that the applicant showed these nicotine pouch products have the potential to provide a benefit to adults who smoke cigarettes and/or use other smokeless tobacco products that is sufficient to outweigh the risks of the products, including to youth

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