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Mutagenic and carcinogenic potential of menadione

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By further elucidating the pathogenic mechanism by which hepatic iron accumulation triggers ferroptosis through the c-Myc-Acsl4 regulatory axis, thereby accelerating the progression of metabolic-associated steatohepatitis (MASH), our research team identified a novel iron chelator, FOT1 (FerroTerminator1, formerly known as CN128), through drug screening, which can prevent and treat the onset and progression of MASH disease [117]

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Aluminum ions facilitate hydrolysis, and the Al 3+ complexes with OH ions while the H + ions remain in the soil solution lowering the pH [23]