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Inhibiting lipid peroxidation can suppress ferroptosis through two primary mechanisms

This system regulates disulfide bond formation, redox-sensitive transcription factors, and apoptosis

Higher plasma concentrations mean stronger effects, including stronger side effects, and in some cases toxicity

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HUVECs, in particular, act as semi-professional antigen-presenting cells, expressing major histocompatibility complex (MHC) class I constitutively and MHC class II in an inducible manner, thus potentially enhancing T-cell activation and distorting disease modelling (199, 200)