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Topical application is the preferred route for cosmetic-adjacent skin research because it delivers the peptide directly to the target tissue while avoiding systemic exposure

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Key cytokines, such as IL-6 and IL-22, along with regulatory immune cells, including Th17, Treg, and Breg cells, play significant roles in modulating the inflammatory response and maintaining mucosal integrity

Thus, immunosuppression (eg, corticosteroid therapy) has the potential to reactivate an HBV infection