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There were similar rates of mild adverse events (e.g., nausea, restlessness, insomnia, irritability) across groups in trials of cytisine based on our initial overview.22 However, an updated Cochrane review on cytisine42 suggested there may be a small increase in adverse events, which could constitute a small harm (4 RCTs, n = 4052

14 Nicotine undergoes additional metabolism through glucuronidation, catalyzed primarily by UGT2B10 15 to form nicotine glucuronide (Nic-Gluc) and oxygenation by flavin monooxygenases (FMOs) including FMO1 and FMO3 16 to form nicotine-N-oxide (NOX)

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The power supply establishes a direct connection to the car battery, ensuring that the current and power align with the battery specifications