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History [edit] Descriptions of deficiency effects [edit] Between 1849 and 1887, Thomas Addison described a case of pernicious anemia, William Osler and William Gardner first described a case of neuropathy, Hayem described large red cells in the peripheral blood in this condition, which he called "giant blood corpuscles" (now called macrocytes), Paul Ehrlich identified megaloblasts in the bone marrow, and Ludwig Lichtheim described a case of myelopathy

Archived from the original on 19 April 2015

Genetic variability in the methylenetetrahydrofolate reductase gene (MTHFR) affects clinical expression of Wilsons disease

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Setting realistic expectations upfront prevents disappointment and helps people make informed decisions about their treatment approach