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This style gained popularity in the United States during the 1980s, with the tobacco leaf wrap contributing a distinctive flavor and a nicotine buzz

Adult rates are falling by around 0.9% per year on average twice as fast as the US and about three times as fast as Australia, where electronic cigarettes are prohibited

These include moderate heterogeneity in some analyses, potential regional biases due to limited global representation, reliance on self-reported exposure in most studies, and a general lack of biomarker-based verification for tobacco exposure

RB is Associate Editor for Frontiers in Pharmacology

Moreover, smoking cigarettes exacerbated gut microbiota dysbiosis in hypertensive individuals, reducing microbial -diversity and shifting enterotypes toward Prevotella -dominant profiles