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The 1964 Surgeon Generals Report reviewed 29 case-control studies and 7 cohort studies

The obtained LogP values were 3.36 for harmane, 3.05 for harmine, and 2.56 for norharman, indicating that harmane has the highest lipophilicity among the three compounds

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Studies have found that MMP14 activity and protein was increased in the airway epithelium of tobacco smoke-exposed mice and decreased MMP14 activity and protein could diminish the mucin 5AC, oligomeric mucus/gel-forming (MUC5AC) transcripts that played significant roles in the development of COPD [104]