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The prefrontal cortex isnt fully developed until around age 25, and using nicotine before then can increase a persons risk of mood disorders, addiction and impaired impulse control

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[then] Im like: Dude, get over yourself, he added

Furthermore, seizure-like activity can emerge from perturbations within small neuronal populations, suggesting microcircuits have an inherent vulnerability operating near excitability thresholds

The vasoconstrictive properties of cocaine can lead to reduced blood flow to vital organs, potentially resulting in heart attacks, strokes, or even sudden death