These AEs are listed below with their rate of incidence in test subjects: Injection site reactions, like pruritus, rash, pain, and swelling (3.1%) Arthralgia (2.4%) Pain in the extremities (1.1%) Myalgia (1.1%) Peripheral edema (1.1%) Paresthesia (0.9%) Hypoesthesia (0.7%) Rash (0.7%) Dyspepsia (0.3%) Muscle pain (0.3%) Pruritus (0.3%) Vomiting (0.3%) Muscle stiffness (0.3%) Carpal Tunnel Syndrome (0.2%) Joint swelling (0.2%) Night sweats (0.2%) Palpitations (0.2%) Furthermore, clinical studies have linked tesamorelin to the following serious adverse events: Increased risk of glucose intolerance Increased risk of type 2 diabetes Disruption of hypothalamic-pituitary axis Neuropathies Lipoatrophy Diarrhea Fever Congestive heart failure Peripheral neuropathy Loss of mobility To date, no long-term tesamorelin studies involving healthy (non-elderly, non-HIV-infected) test subjects have been completed, suggesting that further research is merited
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Effect persistence monitoring: because effects outlast serum presence, endpoint timing should reflect biological process kinetics (days-weeks) rather than serum PK kinetics (hours)
[DOI] [PMC free article] [PubMed] [Google Scholar] Miskei M
