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Bioinformatics (2002) 18:2078.10.1093/bioinformatics/18.1.207 20 TaoufikEPetitEDivouxDTsevelekiVMengozziMRobertsMLet alTNF receptor I sensitizes neurons to erythropoietin- and VEGF-mediated neuroprotection after ischemic and excitotoxic injury
The vast number of individuals affected by this condition, and the approximately 700,000 annual suicide-related deaths, highlight the significant impact it has on public health [33]
When ER stress is excessive or prolonged beyond the adaptive threshold, UPR signaling can shift from cytoprotective to pro-apoptotic outcomes, frequently through crosstalk with mitochondrial death pathways
5A-1MQ-treated mice switched from WD to LD (WD/LD-T) showed a rather reduced relative abundance of Akkermansia compared to vehicle-treated DIO animals switched from WD to LD (WD/LD-V), suggesting a unique microbiome mechanism associated with weight loss in the vehicle-treated group switched from WD to LD compared to the 5A-1MQ-treated group that underwent the same diet switch
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