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Aldose Reductase Inhibitors Aldose reductase inhibitors (ARI) work by blocking the enzyme aldose reductase in the polyol pathway, which under hyperglycemic conditions converts excess glucose into sorbitol, a sugar alcohol that accumulates in nerves and causes osmotic stress, oxidative damage and impaired nerve function [116]

M.et al (2009)

Consistently, a previous study using mammary epithelial cells demonstrated that the BCAAs leucine (Leu), isoleucine (Ile), and valine (Val) enhanced mTORC1 activity, whereas histidine (His), lysine (Lys), and threonine (Thr) suppressed mTORC1 activity (92)

[116-119] What makes Ilex interesting is that it also contains ursolic acid , which is unusual for caffeinated plants

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