However, N-terminal modifications, such as N-acetylation, D-norleucine substitution, or replacement with -aminobutyric acid (GABA), dramatically elongated the peptides half-lives
10.3389/fcimb.2022.938608 102 YamaokaY
DUODENOCUTANEOUS FISTULA IN RATS AS A MODEL FOR WOUND HEALING-THERAPY IN ULCER HEALING: THE EFFECT OF PENTADECAPEPTIDE BPC 157, L-NITRO-ARGININE METHYL ESTER AND L-ARGININE INTRODUCTION We wanted to challenge the understanding of duodenal ulcer disease pathophysiology and therapy, along with Selyes and Szabos cysteamine duodenal lesions, as the mainstay in the duodenal ulcer disease model (1-3), which argues against wound healing therapy (i.e., duodenal ulcer heals like the skin ulcer does)
Representative tissue sections were processed for further histological analysis as described previously[2-7,34]
Researchers often prefer this format when conducting assays, stability testing, or comparative formulation studies