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The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance

Mass spectrometry imaging reveals elevated glomerular ATP/AMP in diabetes/obesity and identifies sphingomyelin as a possible mediator

However, administration of anti-CTLA4 therapy showed potential in slowing disease progression and extend survival in the -SMA + myCAFs depleted model

It regulates blood sugar and boosts metabolism

This method can simultaneously capture common information among different modalities as well as unique information specific to each modality, thereby achieving a more comprehensive and interpretable representation of spatial multi-omics data