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As mentioned earlier, Streptococcus is one of the genera that showed significantly higher abundance in smokeless tobacco non-consumers that was identified by both LEfSe and Boruta analysis

Long-Term Effects of Nicotine Consumption Chronic nicotine consumptionparticularly through combusted tobacco useis associated with a range of health effects, including cardiovascular diseases, respiratory issues, and certain cancers

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Notably, the AF, with lower GCR and LPR than the NP, also primarily contains chondrocyte-like cells, suggesting a shared metabolic profile with the CEP [35, 39]