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Nicotine can also adversely affect the heart, reproductive system, lungs and kidneys

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2004 The first commercial e-cigarette is introduced in China 2006 E-cigarettes are introduced to Europe first, then the United States 2008 In a study funded by Ruyan, a detailed quantitative analysis concludes that, overall the product tested was deemed a safe alternative to smoking. Beginning in 2009, regulatory battles begin on e-cigarettes

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