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Application of quantitative motor assessments in Friedreich ataxia and evaluation of their relation to clinical measures

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Anti-inflammatory effects are associated with the modulation of cytokine activity, which helps limit excessive tissue damage and supports recovery

Replacing the sulfonic acid at position R 1 with a sulfonamide group ( 33 ) resulted in a drastic decrease in solubility of the fragment with a concomitant reduction of binding to TRF1 TRFH by CPMG, whilst the dimethyl sulfonamide 35 or the even bigger benzyl sulfonamide 36 showed an even poorer solubility and a loss of TRF1 TRFH binding (Table 1)