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FIGURE 4 3.4 Nitazoxanide reduced apoptosis in rats with MTX-hepatotoxicity MTX significantly induced hepatic apoptosis as demonstrated by increased proapoptotic markers, Bax level, and caspase-3 activity (Figures 5A, D) while reduced antiapoptotic Bcl-2 level (Figure 5B) and increased Bax/Bcl-2 ratio (Figure 5C) compared to CTRL group

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Recently, many studies have started exploring the role of nutraceuticals in the context of chronic disorders such as cancer, diabetes, atherosclerosis, cardiovascular diseases, and neurological disorders, and interesting results have been achieved [72,73,74,75,76]

Antisense oligonucleotide therapies for neurodegenerative diseases