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Toxins can also deplete the body's stores of SAMe and methionine, which are crucial components of the methylation pathway

ACS Chem Neurosci 2016

Further, expression data from the public database DepMap ( 41 show a positive correlation between PPARG and PLA2G2F expression levels in bladder cancer (Extended Data Fig

Footnotes Abbreviations: CAP = community-acquired pneumonia, COPD = chronic obstructive pulmonary disease, CT = computed tomography, IL = interleukin, MDA = malondialdehyde, NAC = N-acetylcysteine, ROS = reactive oxygen species, SOD = superoxide dismutase, TAOC = total antioxidant capacity, TNF = tumor necrosis factor

Glycolysis converts the 13 C-glucose tracer to M3-pyruvate isotopologues which are oxidized to M2-acetyl-CoA by PDC and finally condensed with oxaloacetate to M2-citrate