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Dosage protocols vary depending on the study model and design

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This assumption is supported by the finding that only the overexpression of GCL, and not of GS, results in increased GSH levels (6)

PMID: 31794058 Milhorat TH, Bolognese PA, Nishikawa M, McDonnell NB, Francomano CA

Bioorg Med Chem Lett 22:18221826 Eaton JK, Furst L, Ruberto RA, Moosmayer D, Hilpmann A, Ryan MJ, Zimmermann K, Cai LL, Niehues M, Badock V, Kramm A, Chen S, Hillig RC, Clemons PA, Gradl S, Montagnon C, Lazarski KE, Christian S, Bajrami B et al (2020) Selective covalent targeting of GPX4 using masked nitrile-oxide electrophiles