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Oxidative Stress, Copper, and Glutathione Regulation of Copper Transport and Cell Viability During Copper Metabolism Copper (Cu) is an essential cofactor in virtually all organisms, and tight control of Cu metabolic pathways are critical for optimal cellular viability

Mass spectrometry analysis of metabolitessample preparation The liver, brain, kidney, and lung tissues were homogenized with a pre-chilled BioPulverizer (59012MS, BioSpec) and then placed on dry ice

Cell Metab 35:15001518 Atkinson MA, Bluestone JA, Eisenbarth GS, Hebrok M, Herold KC, Accili D, Pietropaolo M, Arvan PR, Von Herrath M, Markel DS, Rhodes CJ (2011) How does type 1 diabetes develop?: the notion of homicide or -cell suicide revisited

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