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NNMT inhibition as a therapeutic strategy has been explored in industry pharmaceutical pipelines (including a Pfizer program for non-alcoholic fatty liver disease that was reportedly discontinued in early clinical development), but no NNMT inhibitor has reached regulatory approval to date

Calcium, for example, has an upper limit of 2,000 mg per day for adults 51 and older including food, drink and supplements

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doi: 10.1016/j.bbadis.2017.12.031 62 FallowfieldJAMizunoMKendallTJConstandinouCMBenyonRCDuffieldJSet al

Interestingly, TH transport in the human liver is differentially affected during illness: MCT 8 expression increases in prolonged critical illness compared to acute illness