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An important observation in this study was that the quantities of all the mentioned MMPs were greatly increased in the presence of both keratinocytes and fibroblasts, showing the importance of the crosstalk between keratinocytes and fibroblasts in MMP production, and thus the relevance of a bilayer skin model

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The Food and Drug Administration: New York Times

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In the classic form, it evolves from a macule to a papule and finally to an erosion or ulcer