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This work is suspected of not respecting ethical and scientific standards and is, for some, the subject of ongoing legal proceedings. After years of criticism, including a 2023 letter raising serious concerns about methodological flaws in the study and an editorial conflict of interest (one of the co-authors was also editor-in-chief of the journal), the journal finally issued a lengthy retraction notice

But still no randomized controlled trials specific to hemorrhoids

Accessed June 2026.

Additionally, the Agefine formula incorporates lotion sunscreen to protect against photodamage

The future of metabolic medicine may involve multi-hormone therapies rather than single pathways