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In smokers, there is a decrease in blood ascorbic acid levels and an increase in various oxidative stress markers in blood or urine

Tatsunami R, Oba T, Takahashi K, Tampo Y (2009) Methylglyoxal causes dysfunction of thioredoxin and thioredoxin reductase in endothelial cells

doi: 10.1097/MOL.0000000000000749 35 ZhangKWangXTuJRongHWerzOChenX

Difficulty with Memory or Concentration Vitamin B12 deficiency may affect brain function and contribute to difficulty with memory, focus, or concentration

The advantages of measuring hepatic oxidative status in liver biopsy are that it helps in diagnosis of hepatic dysfunction, reflects the degree of deterioration in the liver tissues, and helps to determine the severity of hepatic injury, and, also, it aids in recommending antioxidants therapy in patients that had a hepatic disease with derangement in hepatic antioxidant constituents