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In patients with mild cognitive impairment (often a precursor to Alzheimers disease), prolonged melatonin supplementation reportedly slowed the progression of cognitive decline and improved sleep and mood, though larger trials are needed
Further analysis revealed that STEAP3 deficiency led to increased intracellular iron levels and ROS accumulation, accompanied by decreased GPX4 expression and impaired cell viability, indicating that STEAP3 depletion induces ferroptosis (Fig
Intriguingly, risk appeared greater among premenopausal women, as well as for estrogen receptor-positive BC cases 280,296
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Gut (2021) 70(10):2015+
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