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Animal care was in compliance with SOPs of Pharmacology Animal facility
The upregulation and activation of 7nAChR subsequently activate several signaling pathways, including neuroprotective PI3K/Akt and Nrf2 pathways, then suppression of pro-apoptotic caspase-3, and suppression of NF-B that reduce the expression of proinflammatory cytokines such as IL-1, and TNF- [50, 86]
Outside of these conditions, GHK-Cu is generally well-tolerated, with minor injection site redness as the most common reported reaction
