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Chemical Composition: What You're Actually Inhaling When comparing 1 cigarette vs 1 joint, the chemical profiles reveal significant differences: Cigarettes contain over 7,000 chemicals, including at least 70 known carcinogens Joints contain cannabinoids, terpenes, and fewer additives, but still produce tar and carbon monoxide when combusted Tobacco smoke contains nicotine, which is highly addictive Cannabis smoke contains THC, which has different addiction potential and mechanisms These chemical differences translate to varying health outcomes