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Lung exposure to fine particulate matter, such as monosodium urate crystals, asbestos, and crystalline silica, results in persistent inflammation, mediated primarily by the NLRP3 inflammasome [72]

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When you do the math (16mL 50mg/mL), you end up with roughly 800mg of total nicotine in the entire device

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Keep the flame close but don't touch the tobacco